Translational Physiology TRANSLATIONAL PHYSIOLOGY A discordance in rosiglitazone mediated insulin sensitization and skeletal muscle mitochondrial content/activity in Type 2 diabetes mellitus
نویسندگان
چکیده
Ines Pagel-Langenickel,* Daniel R. Schwartz,* Ross A. Arena, Diane C. Minerbi, D. Thor. Johnson, Myron A. Waclawiw, Richard O. Cannon III, Robert S. Balaban, Dorothy J. Tripodi, and Michael N. Sack Cardiology Branch, Laboratory of Cardiac Energetics and the Office of Biostatistics Research, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland; Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, Indiana; and the Departments of Physiology and Physical Therapy, Virginia Commonwealth University, Richmond, Virginia
منابع مشابه
A discordance in rosiglitazone mediated insulin sensitization and skeletal muscle mitochondrial content/activity in Type 2 diabetes mellitus.
Skeletal muscle mitochondrial dysfunction is hypothesized to contribute to the pathophysiology of insulin resistance and Type 2 diabetes. Whether thiazolidinedione therapy enhances skeletal muscle mitochondrial function as a component of its insulin-sensitizing effect is unknown. To test this, we evaluated skeletal muscle mitochondria and exercise capacity in Type 2 diabetic subjects with other...
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The temporal changes in skeletal muscle mitochondrial content and lipid metabolism that precede type 2 diabetes are largely unknown. Here we examined skeletal muscle mitochondrial fatty acid oxidation (MitoFAOX) and markers of mitochondrial gene expression and protein content in sedentary 20- and 40-wk-old hyperphagic, obese Otsuka Long-Evans Tokushima fatty (OLETF-SED) rats. Changes in OLETF-S...
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Introduction Skeletal muscle mitochondrial dysfunction and excessive accumulation of intramyocellular lipids (IMCL) have been implicated in the development of insulin resistance [1-2]. Thiazolidinediones (TZDs), such as pioglitazone and rosiglitazone, are insulin-sensitizing drugs that are commonly used to treat patients with type 2 diabetes. TZDs act on the PPAR-γ receptor thereby stimulating ...
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Insulin resistance or diabetes is associated with limited exercise capacity, which can be caused by the abnormal energy metabolism in skeletal muscle. Oxidative stress is involved in mitochondrial dysfunction in diabetes. We hypothesized that increased oxidative stress could cause mitochondrial dysfunction in skeletal muscle and make contribution to exercise intolerance in diabetes. C57/BL6J mi...
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